The M8 and O8 are not only microscopes, but also digital scanners. They can be programmed to scan a slide (or slides, or parts of a slide, or parts of slides) in ultra-high resolution and with stunning colour definition. Once your slide is scanned, use ViewPoint, our free slide viewer software, to view the sample. Zoom seamlessly through the slides with your fingers or mouse, enabled by the concept of intuitive operation. Annotations, measurements, multiple fields of view, counting and other software based applications empower you and your work.
Slide Scan offers five microscope slide scanning modes along with other features. These scanning modes vary in speed and quality, giving you the option to choose the most appropriate scan configuration for your needs.
In Slide Scan mode, the M8 and O8 immediately provide a large thumbnail overview of your microscope slide. With this overview, it is possible to mark the scan areas, rather than scanning the entire slide to save time. In order to select the best scan configuration for digitising your microscope slides, it is necessary to first examine the sample. Use the Live View Mode or Instant Scan Mode to assess the slide topology, or the evenness of the slide. Depending on the topology, it is possible to determine whether a small or large focus range is necessary. An even slide with many focus regions will require a smaller focus range, while an uneven slide requires a larger focus range. After evaluation, go to Slide Scan mode and determine the Scan Configuration to choose your scan modes and to select your scan features.
A unique feature of these microscope scanners is that they have the possibility to scan even “unusual” slides. Slides with a special “thickness” or samples embedded in plastic are all possible to be shown with clarity.
Here we further explain the different scan modes, individualised for your specific purposes.
No Focus: This is the fastest scan mode and specifically suitable for completely even-surfaced or flat samples. In the few cases that the sample is focused throughout the slide, the M8 and O8 both run autofocus at one selected point, then scans the image without changing its Z-position during the scan.
Predictive Focus: This mode is for relatively even surfaced samples. Both microscope scanners use different focus points to extract a best fitting focal plane for the scan. They then drive along this abstracted focus plane while scanning the slide, without changing its Z-position for each tile.
Intelligent Focus: This is the default mode of the scan configuration and usually the best option in balancing speed and quality. Just like in the Predictive Focus mode, the M8 and O8 use focus points to estimate the best fitting focal plane to drive along with its Z-position. Then, in the Intelligent Focus mode, it is necessary to specify your focus range between 10 and 400µ, based on the slide topology. The focus range determines how much the Z-position should drive vertically in either direction for each tile scanned during the scan. As the Z-position drives along the z-axis, the microscope scanners find the sharpest focus point in the specified range to select the best image for your digitised slide.
Autofocus: This mode delivers exclusively focused images and is especially suitable for slides with large differences in height. Just like in Intelligent Focus, it is necessary to select the focus range in which the M8 and O8 run the Z-position along. However, they do not abstract a focus plane to run along, but rather focus on each tile starting at the same determined point on the z-axis.
Focus Fusion: This mode is really useful for very uneven objects on the whole slide. Just like in the Intelligent Focus and Autofocus scan modes, the focus range must be selected. However, in Focus Fusion, as the Z-position drives along this range, it is not selecting the best image, but rather collecting the best pixels from each individual image, among the stack of images. Then, this scanning mode merges the best pixels as one fully sharp image, thereby guaranteeing the best possible focus beyond the “image” level, to the “individual pixel” level.
Once the chosen scan mode is selected the scan configuration can be set up:
Detect Focus Plane: This feature is selected by default but can be adjusted manually. The M8 and O8 will use a focus point to detect the approximate location of the sample before starting the scan. This is generated using our own algorithm.
Perform Illumination Correction: This feature is selected by default but can be adjusted manually. Illumination Correction homogenises the background illumination to eliminate any uneven tiling pattern. To do this, the M8 and O8 identify a whitespace, or a clear area without a sample. Then this whitespace is replicated throughout the whole slide to correctly illuminate the sample with the optimal white balance.
Sparse Scan: With this feature, the M8 and O8 skip scanning selected scanning areas that do not contain tissue. This feature helps to decrease overall scan time.
High Speed Scan: This feature is only available in Intelligent Focus mode. High Speed Scan only uses the autofocus feature in every other column and every other row of the scan grid. When autofocus is not used, the images are acquired at an estimated Z-position.
Once you select your scan configuration, begin scanning right away and view your scanned slides on ViewPoint. Please note that MicroPoint and ViewPoint are licence-free so can be installed on any number of PCs. Remote control requires connection via Windows Remote Assistant, TeamViewer or similar – MicroPoint does not need to be installed. A Mac, PC, tablet or smartphone can be used to remotely control the M8 and O8 but the image quality will be compromised unless a 2K monitor (or better) is used.
The PreciPoint M8 and O8 are dual purpose microscopes and whole slide scanners with live remote control functionality. Although they can be controlled via a Windows PC with a 2K (or, preferably, 4K) monitor, the best experience comes when using a high resolution touch screen computer – making it a truly “hands on” digital microscope. The intuitive software allows for easy navigation through your microscope slides with just the touch of your fingers. Perfect for frozen section consultations.
With everything automated and digitised, there is no need for oculars and manual focus knobs and no need for the condenser to be focussed and centred. Everything can be controlled remotely and working with a touchscreen computer, a tablet or a smartphone makes you feel as if you could examine the sample with your own hands, literally! The M8 is the most ergonomic and intuitive microscope/scanner on the market today.
The PreciPoint M8/O8 digital microscope enables you to work from anywhere at any time. Access and operate the M8 remotely and in real-time (telepathology); connect, share and discuss your findings with your colleagues and specialists from all over the world.
“The M8 is the ‘missing link‘ when it comes to remote control microscopy; pathologists have needed it for years!” according to Dr. J.B. Askew, Houston, TX.
The secret to the power and appeal of these microscope scanners are their incredibly fast live stitching feature. You can zoom seamlessly through the slide as if you could examine the sample with your own hands. While doing so, the M8 and O8’s extremely powerful, but very easy-to-use MicroPoint software concatenates individual images to a high resolution, full screen image, making your work easier and faster. Pathologists can remotely zoom, pan and scroll instantly anywhere on an image! The overview image is cached prior to review allowing immediate access to any part of the sample, without the need to refocus, with the “feel of using a microscope”. An amazingly large field of view of the entire microscope slide is produced within seconds.
These microscope scanners are so revolutionary you have to “SEE IT TO BELIEVE IT!” Focusing and brightness correction are automatic. Adjust gamma, sharpen and enhance images in split seconds. Annotate, draw and share all or selected regions of interest (ROI) in real-time. Use either 20x, 40x or 60x Plan Fluorite or Plan Apochromatic objectives, manufactured by Olympus. Although it is unlikely you will need to change objectives, they are easily interchangeable in seconds and pre-aligned! No time consuming re-calibration is needed as the calibration of every objective is stored with the software.
Besides real-time scanning of up to 5 standard 75 x 25mm slides, the M8 and O8 are also one of the few products capable of scanning oversized and non-standard slides. The adjustable slide holder accommodates a variety of slide sizes including 75 x 50mm geological slides. Most competing scanner manufactures have ZERO tolerance when it comes to slide holders.
“I love to use the digital microscope. It’s much easier to operate.”
- Sarah Just, PhD Candidate, Technical University of Munich (TUM)
“The touchscreen makes research more fun.”
- Dr. Olivia Cole, Senior Scientist, Technical University of Munich (TUM)
“Looking through 600 to 800 slides on the M8 is 3 – 4 times faster than a normal microscope. It’s brilliant!”
- Sandra Haßelt, Medical Technical Laboratory Assistant, Ludwig Maximilian University of Munich
Contact us on (+44) 01865 400321 or firstname.lastname@example.org
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